Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloromethyl-1,4-dimethoxy-naphthalene → tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloromethyl-1,4-dimethoxy-naphthalene | HCID 14854802 | — |
| 반응물 | tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate | HCID 54504409 | — |
| 생성물 | tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate | HCID 53716657 | — |
반응 단계
In an analogous manner to that described in Example 1 (g), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate [Example 122 (b)] with 2-chloromethyl-1,4-dimethoxy-naphthalene [J.Org.Chem. (1983), 48(19),3265-3268] there was obtained tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate as a colourless, viscous oil; MS: 626 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06051712 |
| 출처 데이터셋 | uspto-grants-2000_04 |
| ORD ID | ord-37c2fde6464b480a959bbf96eef335fb |
| 출처 메모 | uspto-grants-2000_04 |