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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1005168생성일: 2026년 10월 27일

1-(Chloromethyl)-4-(methylthio)benzene → tert-butyl (3RS,4RS)-3-(4-methylsulfanyl-benzyloxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate

https://huagongshe.com/reaction/1005168

반응식

참여 물질

역할이름HCID투입량
반응물1-(Chloromethyl)-4-(methylthio)benzeneHCID 70128—
반응물tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylateHCID 86604483—
생성물tert-butyl (3RS,4RS)-3-(4-methylsulfanyl-benzyloxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylateHCID 54342139—

반응 단계

In an analogous manner to that described in Example 1 (g), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate with 4-methylthio-benzyl chloride [J.Org.Chem. (1988), 53(3), 561-569] there was obtained tert-butyl (3RS,4RS)-3-(4-methylsulphanyl-benzyloxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate as a colourless oil; MS: 578 (M+H)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06051712
출처 데이터셋uspto-grants-2000_04
ORD IDord-1187fd182fe140f6be432ae693889fca
출처 메모uspto-grants-2000_04