Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylaniline → (Methyl-phenyl-amino)-acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylaniline | HCID 7515 | — |
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (Methyl-phenyl-amino)-acetic acid ethyl ester | HCID 265936 | — |
반응 단계
A solution of 16.7 g (100 mmol) of ethyl bromoacetate, 10.7 g (100 mmol) of N-methylaniline, and 12.9 g (100 mmol) of N,N-diisopropylethylamine in 100 mL of acetonitrile was allowed to stand for 24 hr. and then diluted with 200 ml of ether. The amine salt was filtered and the filtrate concentrated, dissolved in 150 ml of CH2Cl2, washed with water, filtered through a plug of sodium sulfate/silica and distilled: 15.5 g (80%), b.p. 132°/12 mm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06054260 |
| 출처 데이터셋 | uspto-grants-2000_04 |
| ORD ID | ord-43b4e9700bb941738da9a22017179fa1 |
| 출처 메모 | uspto-grants-2000_04 |