HCID 178496563, 화합물 → HCID 178496562, 화합물

HRID 1005416

반응식

HRID 1005416 반응식
[N+:1]([C:4]1[C:5](=[O:20])[N:6]([CH2:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([O:18][CH3:19])[CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[CH3:10])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[C:5](=[O:20])[N:6]([CH2:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([O:18][CH3:19])[CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[CH3:10]

참가 물질

4

반응물 1

HCID 178496563HCID 178496563, 화합물

생성물 1

HCID 178496562HCID 178496562, 화합물수율 91.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of cis-3-nitro-1-(4-methoxycyclohexylmethyl)-4-methyl-2-pyridone (0.16 g, 0.57 mmol) and 10% Pd/C (0.06 g) in ethanol was hydrogenated at 50 psi in a Parr apparatus for 22 hours. The catalyst was removed by filtration, and the solvent was evaporated to give cis-3-amino-1-(4-methoxycyclohexylmethyl)-4-methyl-2-pyridone (0.13 g, 0.52 mmol, 91%).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-17023b8a932f4e72a16d376efc691c00
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06054470

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