Triethylamine → 5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-2-(1-methoxycyclohexyloxy)methyl-1H-imidazole

HRID 1005515

반응식

HRID 1005515 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][OH:17])=[N:12][C:11]=2[CH:18]([CH3:20])[CH3:19])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH+]1C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:38][O:39][C:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH:41]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[Cl:8][C:6]1[CH:5]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH2:16][O:17][C:40]3([O:39][CH3:38])[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]3)=[N:12][C:11]=2[CH:18]([CH3:20])[CH3:19])[CH:3]=[C:2]([Cl:1])[CH:7]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 702641-MethoxycyclohexeneHCID 473916(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl)methanolHCID 22033616Pyridinium.p-toluenesulfonate

생성물 1

HCID 187920075-(3,5-Dichlorophenylthio)-4-isopropyl-1-methyl-2-(1-methoxycyclohexyloxy)methyl-1H-imidazole수율 83.4%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 5-(3,5-dichlorophenylthio)-4-isopropyl-1-methyl-2-hydroxymethyl-1H-imidazole (14) (33 mg, 0.1 mmol) prepared in accordance with the method as described in WO 96/10019 and p-toluenesulfonic acid pyridinium (27.6 mg, 0.11 mmol) in toluene (1.5 mL) was added 1-methoxycyclohexene (112 mg, 1.00 mmol) under ice-cooling, and stirred at room temperature for 6 hours. A drop of triethylamine was added to the reaction mixture, and the mixture was filtered to remove the insoluble matter. The filtrate was concentrated under reduced pressure. The residue was purified by chromatography on an alumina column (eluate: toluene) to give the compound 15 (37.0 mg, 70%) as oil. Rf 0.16 (Al2O3 60, Type E, toluene).

후처리

  1. temperaturecooling
  2. filtrationthe mixture was filtered
  3. customto remove the insoluble matter
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customThe residue was purified by chromatography on an alumina column (eluate: toluene)

출처 및 근거

ORD 기록
ord-a286971f7e184e91b02b73dd4c884107
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06054591

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