Carbamate → 5-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-ylmethyl 3,5-dichlorobenzoylcarbamate

HRID 1005551노트

반응식

HRID 1005551 반응식
[OH:1][CH2:2][C:3]1[N:4]([CH2:20][CH3:21])[C:5]([S:11][C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.C(=O)([O-])N.[Cl:26][C:27]1[CH:28]=[C:29]([CH:35]=[C:36]([Cl:38])[CH:37]=1)[C:30]([N:32]=[C:33]=[O:34])=[O:31]>>[Cl:26][C:27]1[CH:28]=[C:29]([CH:35]=[C:36]([Cl:38])[CH:37]=1)[C:30]([NH:32][C:33](=[O:34])[O:1][CH2:2][C:3]1[N:4]([CH2:20][CH3:21])[C:5]([S:11][C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)=[C:6]([CH:8]([CH3:9])[CH3:10])[N:7]=1)=[O:31]

참가 물질

4

반응물 3

HCID 276CarbamateHCID 473933(5-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-yl)methanolHCID 135133493,5-Dichlorobenzoyl isocyanate

생성물 1

HCID 4781915-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-ylmethyl 3,5-dichlorobenzoylcarbamate수율 78%

실험 절차

The compound 19 (300 mg, 0.869 mmol) was converted to the carbamate with 3,5-dichlorobenzoyl isocyanate (1.5 eq.) in the same manner as the example 66 to give the compound 87 (380 mg, 78%) as crystals. Mp.124-125° C. Rf 0.23 (1:2 EtOAc-hexane)

출처 및 근거

ORD 기록
ord-c94c5db179054fd083e5aa12ed35038c
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06054591

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