Water → N-Acetyl-N-(3-ethoxycarbonylaminophenethyl)amine

HRID 1005684노트

반응식

HRID 1005684 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH2:13])[CH:8]=1)(=[O:3])[CH3:2].Cl[C:15]([O:17][CH2:18][CH3:19])=[O:16].O>N1C=CC=CC=1>[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:8]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 10928Ethyl chloroformateHCID 22674097N-Acetyl-N-(3-aminophenethyl)amine

생성물 1

HCID 22674171N-Acetyl-N-(3-ethoxycarbonylaminophenethyl)amine수율 97%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In pyridine (5 ml) was dissolved 1.7 g of N-acetyl-N-(3-aminophenethyl)amine (Preparation Example 29), followed by dropwise addition of ethyl chloroformate (1.4 ml) under ice-cooling. After stirring at room temperature for 1 hour, the mixture was ice-cooled again. Water was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (2.358 g, 97%) as a yellow oil.

후처리

  1. temperaturecooling
  2. temperaturecooled again
  3. extractionby extracting with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-d50f8460846d43158c9a1f4863c7c1ca
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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