Potassium Carbonate → 6-Ethoxycarbonylamino-1-methyl-3,4-dihydroisoquinoline

HRID 1005685노트

반응식

HRID 1005685 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:8]=1)(=O)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>>[CH2:17]([O:16][C:14]([NH:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[C:1]([CH3:2])=[N:4][CH2:5][CH2:6]2)=[O:15])[CH3:18]

참가 물질

3

반응물 2

HCID 11430Potassium CarbonateHCID 22674171N-Acetyl-N-(3-ethoxycarbonylaminophenethyl)amine

생성물 1

HCID 226741196-Ethoxycarbonylamino-1-methyl-3,4-dihydroisoquinoline

실험 절차

Using 1.0 g of N-acetyl-N-(3-ethoxycarbonylaminophenethyl)amine (Preparation Example 30), cyclization reaction was conducted according to the procedure described in Heterocycles 31(2), 341 (1990). After the completion of the reaction, the reaction mixture was poured onto ice, the mixture was basified with potassium carbonate, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound as brown oil.

후처리

  1. customAfter the completion of the reaction
  2. additionthe reaction mixture was poured onto ice
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-ecefc55a51014799b27966792eb14a58
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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