Pyridine-3-sulfonyl chloride → HCID 10292214, 화합물

HRID 1005693노트

반응식

HRID 1005693 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7](Cl)(=[O:9])=[O:8])[CH:2]=1.[NH2:11][C:12]1[CH:13]=[N:14][C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][C:16]=2[Br:22]>N1C=CC=CC=1>[Br:22][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:15]=1[N:14]=[CH:13][C:12]([NH:11][S:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)(=[O:9])=[O:8])=[CH:21]2

참가 물질

4

반응물 2

HCID 3164136Pyridine-3-sulfonyl chlorideHCID 226741618-Bromoquinolin-3-amine

생성물 1

HCID 10292214HCID 10292214, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매2회

실험 절차

In pyridine (5 ml) was dissolved 3-amino-8-bromoquinoline (Preparation Example 5) was dissolved in pyridine (5 ml), and 3-pyridinesulfonyl chloride (254 mg) was added thereto, followed by stirring at room temperature for 30 minutes. After the completion of the reaction, the reaction mixture was poured onto brine, and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and then concentrated. The resulting crude crystals were washed with ethyl acetate and IPA, to give the title compound (270 mg).

후처리

  1. customAfter the completion of the reaction
  2. additionthe reaction mixture was poured onto brine
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated
  6. washThe resulting crude crystals were washed with ethyl acetate and IPA

출처 및 근거

ORD 기록
ord-8380505b3fff4ff09bb58d17a94a55ad
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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