Pyridine → HCID 22674187, 화합물

HRID 1005695노트

반응식

HRID 1005695 반응식
N1C=CC=CC=1.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1.[NH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][C:25]=2[Cl:29])[N:20]=1>O>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][C:25]=3[Cl:29])[N:20]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 140674265-Chloroquinolin-2-amine

생성물 1

HCID 22674187HCID 22674187, 화합물수율 8.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Pyridine (1 ml) and 4-chlorobenzenesulfonyl chloride (255 mg) were added to 2-amino-5-chloroquinoline (119 mg, Preparation Example 2) at room temperature. After stirring at room temperature for 3 days, water was added thereto and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate and concentrated. Then, the resulting solid was washed with methanol, to give the title compound (20 mg).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. washThen, the resulting solid was washed with methanol

출처 및 근거

ORD 기록
ord-5ff07c5c102b42ff9ce5f9e6d1eb24e8
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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