Water → HCID 59083366, 화합물

HRID 1005698노트

반응식

HRID 1005698 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Br:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1.O>N1C=CC=CC=1>[Br:12][C:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][S:20]([C:17]3[CH:18]=[CH:19][C:14]([Cl:13])=[CH:15][CH:16]=3)(=[O:22])=[O:21])=[CH:3][CH:4]=2)[CH:9]=[N:8][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 73984-Chlorobenzenesulfonyl chlorideHCID 226740574-Bromo-7-isoquinolinamine

생성물 1

HCID 59083366HCID 59083366, 화합물수율 36.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In 1.5 ml of pyridine was dissolved 20 mg (0.09 mmol) of 7-amino-4-bromoisoquinoline (Preparation Example 20), 23 mg of 4-chlorobenzenesulfonyl chloride was added thereto, followed by stirring at room temperature overnight. To the reaction mixture was added water, followed by extracting with ethyl acetate. The extract was dried over magnesium sulfate and concentrated. Then, the resulting residue was purified by silica gel thin layer chromatography, to give 13 mg of the title compound. Melting point: gradually decomposed from 229 degrees.

후처리

  1. additionwas added
  2. extractionby extracting with ethyl acetate
  3. dry with materialThe extract was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customThen, the resulting residue was purified by silica gel thin layer chromatography

출처 및 근거

ORD 기록
ord-34de48a57a364b019add73319d38723c
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787534B2

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