Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxypyrrolidine → 4-Hydroxy-1-(4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-pyrrolidine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxypyrrolidine | HCID 98210 | — |
| 반응물 | Cis-4-Hydroxy-D-Proline | HCID 440014 | — |
| 반응물 | 2-Chloro-4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine | HCID 21906809 | — |
| 생성물 | 4-Hydroxy-1-(4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-pyrrolidine-2-carboxylic acid | HCID 21906754 | — |
반응 단계
The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with cis-4-hydroxy-D-proline. A yellow solid 109 was obtained (0.030 g, 63%). MS (APCI) m/z 491 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06787542B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-c6c5e280662c498a905444e6a101154e |
| 출처 메모 | uspto-grants-2004_09 |