1-(5-Bromopyrimidin-2-yl)piperazine → tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2C=CC(Br)=CC=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:21][C:22]1[CH:23]=[N:24]C(N2CCNCC2)=[N:26][CH:27]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[N:24]=[CH:23][C:22]([Br:21])=[CH:27][N:26]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

참가 물질

반응물 2

HCID 27571751-(5-Bromopyrimidin-2-yl)piperazine

HCID 11824027Tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate

생성물 1

HCID 21914476tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate수율 93%

실험 절차

Prepared according to the method for the preparation of 4-(4-bromophenyl)-piperazine-1-carboxylic acid ter-butyl ester, from 5-bromo-2-piperazin-1-ylpyrimidine (5.00 g), to yield the title compound as a white solid (6.55 g, 93%)

후처리

customPrepared

출처 및 근거

ORD 기록: ord-2cf6e21bb76944739c9754a15b52d95f
출처 데이터셋: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06787536B2

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