Pyridine → 2-(5-Tosyloxy-pentyloxy)pyridine

HRID 1005954노트

반응식

HRID 1005954 반응식
N1C=CC=CC=1.[C:7]1([CH3:17])[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=1.[OH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1>ClCCl>[S:13]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)([C:10]1[CH:11]=[CH:12][C:7]([CH3:17])=[CH:8][CH:9]=1)(=[O:15])=[O:14]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 121371182-(5-Hydroxypentyloxy)pyridine

생성물 1

HCID 121371192-(5-Tosyloxy-pentyloxy)pyridine수율 54.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5 ml of pyridine and 7 g of p-toluenesulfonyl chloride were added to a solution of 6.5 g of the compound obtained in Example 3a in 20 ml of dichloromethane and then the mixture was stirred for 4 hours. The organic layer was washed with 10% aqueous citric acid and then with water and dried over sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate) to obtain 6.57 g of the title compound (yield: 53%).

후처리

  1. washThe organic layer was washed with 10% aqueous citric acid
  2. dry with materialwith water and dried over sodium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customthe resulting residue was purified by silica gel column chromatography (ethyl acetate)

출처 및 근거

ORD 기록
ord-3b2996a94c454792a4f6f0e091413eaa
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787561B1

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