Anthranilic Acid → ortho-aminophenylbenzoxazole

반응식

[C:1]([OH:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1O>>[NH2:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]1[O:10][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]=1

참가 물질

반응물 2

HCID 227Anthranilic Acid

HCID 58012-Aminophenol

생성물 1

HCID 4602658ortho-aminophenylbenzoxazole수율 49%

실험 절차

The reaction of 13.71 g (0.10 mole) of anthranilic acid with 10.91 g (0.10 mole) of ortho-aminophenol was carried out in 100 ml of polyphosphoric acid at 200° C. After 10 hours from the start of the reaction, the reaction mixture was poured into ice water and the precipitate was filtered and dried. The solid thus obtained was purified by column chromatography and concentrated to give 10.28 g (0.048 mole, 49%) of ortho-aminophenylbenzoxazole.

후처리

customAfter 10 hours from the start of the reaction
filtrationthe precipitate was filtered
customdried
customThe solid thus obtained
customwas purified by column chromatography
concentrationconcentrated

출처 및 근거

ORD 기록: ord-3186a28d983d441fbe66548a3c4dcfec
출처 데이터셋: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06790540B2

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