Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Benzylpiperazine → 1-triisopropylsilanyl-4-(4-benzyl-piperazin-1-yl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Benzylpiperazine | HCID 75994 | — |
| 반응물 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 반응물 | 4-bromo-1-(triisopropylsilyl)-1H-indole | HCID 2795573 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 1-triisopropylsilanyl-4-(4-benzyl-piperazin-1-yl)-1H-indole | HCID 22671261 | — |
반응 단계
A mixture of 1.0 g (2.8 mmole) 4-bromo-triisopropylsilanyl-1H-indole, 0.54 mL (3.1 mmole) N-benzylpiperazine, 31 mg (0.14 mmole) palladium(II)acetate, 28 mg (0.14 mmole) tri-t-butylphosphine and 403 mg sodium t-butoxide in 5 mL xylene was heated at 120° for 15 hours. The reaction mixture was diluted with 100 mL 50% ether-hexane and filtered through a pad of silica gel 230-400 mesh. The filtrate was concentrated under reduced pressure to afford 1-triisopropylsilanyl-4-(4-benzyl-piperazin-1-yl)-1H-indole as a semi-solid, 1.2 g, M+H=448.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06790848B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-d5112bf2dea042d1bf1a27dcc81af0ac |
| 출처 메모 | uspto-grants-2004_09 |