Water → 4-[2-(Benzyloxymethoxy)ethyl]aniline

HRID 1006455노트

반응식

HRID 1006455 반응식
[CH2:1]([O:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[CH:25]=[CH:24][C:16]([NH:17]C(=O)C(F)(F)F)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[CH:25]=[CH:24][C:16]([NH2:17])=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 226719434'-[2-(Benzyloxymethoxy)ethyl]-2,2,2-trifluoroacetanilide

생성물 1

HCID 226719344-[2-(Benzyloxymethoxy)ethyl]aniline수율 87.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4′-[2-(benzyloxymethoxy)ethyl]-2,2,2-trifluoroacetanilide (9.7 g) in methanol (50 ml) were added water (30 ml) and potassium carbonate (3.3 g), and the mixture was stirred for 24 hours at room temperature. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gave 4-[2-(benzyloxymethoxy)ethyl]aniline (6.2 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customRemoval of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-3c4afb8338964e06aa072ed13e89e50c
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790865B2

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