2-nitro-5-trifluoromethylphenyl Methoxymethyl Ether → 2-amino-5-trifluoromethylphenyl Methoxymethyl Ether
반응식
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[N+:15]([O-])=O>CO.[Pd]>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:8]=[CH:7][C:6]=1[NH2:15]참가 물질
4
실험 절차
To a solution of 2-nitro-5-trifluoromethylphenyl methoxymethyl ether (353 mg; prepared in Reference Example 19.) in MeOH (3.5 ml), 10% Pd—C (30 mg) was added in a stream of argon. The mixture was stirred vigorously at room temperature under hydrogen atmosphere. The reaction mixture was filtered through celite and concentrated under the reduced pressure to give the title compound (313 mg) having the following physical data.
후처리
- filtrationThe reaction mixture was filtered through celite
- concentrationconcentrated under the reduced pressure
출처 및 근거
- ORD 기록
- ord-896df9e5cdeb4ef8881b9d572933c779
- 출처 데이터셋
- uspto-grants-2004_09
- 특허 번호
- US06790866B2
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