Allyl Alcohol → Benzoic acid, 4-(hydroxymethyl)-3-nitro-, 2-propenyl ester

HRID 1006647노트

반응식

HRID 1006647 반응식
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[N+:12]([O-:14])=[O:13].[CH2:15](O)[CH:16]=[CH2:17]>>[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([O:9][CH2:17][CH:16]=[CH2:15])=[O:8])=[CH:5][C:4]=1[N+:12]([O-:14])=[O:13]

참가 물질

3

반응물 2

HCID 7858Allyl AlcoholHCID 15018924-Hydroxymethyl-3-nitrobenzoic acid

생성물 1

HCID 11118069Benzoic acid, 4-(hydroxymethyl)-3-nitro-, 2-propenyl ester

실험 절차

In a 100 mL round bottom flask was placed 4-hydroxymethyl-3-nitrobenzoic acid (1.97 g, 10 mmol). Allyl alcohol (20 mL) was added, followed by p-toluensesulfonic acid (0.190 g, 1 mmol). The mixture was heated to reflux for 24 hr., at which time all the volatiles were removed in vacuo. The residue was taken up in EtOAc and washed with sat'd KHCO3. The organic layer was dried over MgSO4 and concentrated to afford the title compound as a cream colored solid; 2.4 g (100%).

후처리

  1. customIn a 100 mL round bottom flask was placed
  2. temperatureThe mixture was heated
  3. temperatureto reflux for 24 hr
  4. custom, at which time all the volatiles were removed in vacuo
  5. washwashed with sat'd KHCO3
  6. dry with materialThe organic layer was dried over MgSO4
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-52237e93909a4cc8b322c8dce251e7f4
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790965B1

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