Water → HCID 22672646, 화합물

HRID 1006673노트

반응식

HRID 1006673 반응식
C[O:2][C:3]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1.B(Br)(Br)Br.O>C(Cl)Cl>[OH:2][C:3]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 22672579HCID 22672579, 화합물

생성물 1

HCID 22672646HCID 22672646, 화합물수율 57%

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

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온도
-73 °C

실험 절차

8-(2-methoxy-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine (0.14 g, 0.48 mmol) was solved in methylene chloride (9 ml) and the mixture was cooled to −73° C. Boron tribromide in methylene chloride (1M) (2.37 ml, 2.37 mmol) was added dropwise and the mixture was stirred for 20 h. in a nitrogen atmosphere and the temperature was allowed to raise to room temperature. The reaction mixture was cooled on ice and ice, water and methylene chloride were added. The organic layer was separated, washed with saturated sodium bicarbonate, dried and evaporated under reduced pressure to give 0.077 g (57%) of the title compound

후처리

  1. temperatureto raise to room temperature
  2. additionwere added
  3. customThe organic layer was separated
  4. washwashed with saturated sodium bicarbonate
  5. customdried
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a00155eca5e24e6f985f0bfeee20a1c7
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790960B2

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