참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | 2-Bromo-1-(bromomethyl)-3-methylbenzene | HCID 10934320 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(2-Bromo-3-methylphenyl)acetonitrile | HCID 22672613 | 44.1% |
반응 단계
A mixture of 2-brom-3-methylbenzylbromide (25 g, 0.095 mol) and potassium cyanide (16 g, 0.25 mol) in dimethylformamide (100 ml) was stirred at 90° C. for 20 h. The solvent was evaporated under reduced pressure and to the residue were added toluene and water. The organic layer was separated washed with water, separated and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 8.8 g (44%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06790960B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_09 |
|---|
| ORD ID | ord-9ba3ef7949d34f6181be2d166926885e |
|---|
| 출처 메모 | uspto-grants-2004_09 |
|---|
