Acetamide, 2-bromo-N-butyl-N-methyl- → 2-(acetylthio)-N-butyl-N-methylacetamide
반응식
Br[CH2:2][C:3]([N:5]([CH2:7][CH2:8][CH2:9][CH3:10])[CH3:6])=[O:4].[C:11]([O-:14])(=[S:13])[CH3:12].[K+]>CO>[C:11]([S:13][CH2:2][C:3]([N:5]([CH2:7][CH2:8][CH2:9][CH3:10])[CH3:6])=[O:4])(=[O:14])[CH3:12]참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
4.16 g of bromo-N-butyl-N-methylacetamide of Preparation B of Example 78, Step A in 1.5 ml of methanol were added to a suspension of 2.28 g of potassium thioacetate in 10 ml of methanol and the mixture was heated for one hour at 40° C. under an argon atmosphere. After evaporation to dryness under reduced pressure, the residue was dissolved with ethyl ether, the insoluble part filtered off and the solution was evaporated to dryness to obtain 4.06 g of oily product.
후처리
- customAfter evaporation to dryness under reduced pressure
- dissolutionthe residue was dissolved with ethyl ether
- filtrationthe insoluble part filtered off
- customthe solution was evaporated to dryness
출처 및 근거
- ORD 기록
- ord-686997355a1c4c90be147b7716837c98
- 출처 데이터셋
- uspto-grants-2004_09
- 특허 번호
- US06790971B1
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