Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 1,3-Dichloroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1,3(2H,4H)-isoquinolinedione | HCID 349435 | — |
| 반응물 | Phenylphosphonate dichloride | HCID 22048082 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1,3-Dichloroisoquinoline | HCID 298625 | — |
반응 단계
A mixture solution of homophthalimide (10.5 g) and phenylphosphonate dichloride (30 ml) was heated at 110° C. for 2 hr. After the reaction mixture was cooled, water was added thereto, and then the resulting mixture was neutralized with sodium carbonate. The resulting mixture was extracted with ethyl acetate, washed with brine, dried, and then the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (methylene chloride), to give 9.30 g of the title compound as white crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06790844B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-6979a33c740f4041a597c027f56fc455 |
| 출처 메모 | uspto-grants-2004_09 |