Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 3-[4-(4-Morpholinyl)phenyl]isoquinolin-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Fluorobenzonitrile | HCID 14517 | — |
| 반응물 | N-methyl-2-toluamide | HCID 75111 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3-[4-(4-Morpholinyl)phenyl]isoquinolin-1-one | HCID 22503318 | 41.5% |
반응 단계
4-(4-Morpholinyl)benzonitrile obtained by reacting 4-fluorobenzonitrile (10.89 g) and morpholine (7.84 g) in the presence of potassium carbonate (12.42 g) in dimethyl sulf oxide (45 ml) was reacted with N-methyl-o-toluamide (8.019 g) according to Example 10-1, to give 6.840 g of 3-[4-(4-morpholinyl)phenyl]isoquinolin-1-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06790844B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-bfb04973d50f447d9915484061949813 |
| 출처 메모 | uspto-grants-2004_09 |