참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 2-[4-(Acetyloxy)-3-fluorophenyl]-7-vinyl-1,3-benzoxazol-5-yl acetate | HCID 11268263 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Prinaberel | HCID 656954 | 56.7% |
반응 단계
Potassium carbonate (55 mg) was added into a solution of 2-[4-(acetyloxy)-3-fluorophenyl]-7-vinyl-1,3-benzoxazol-5-yl acetate (0.14 g, 0.39 mmol) and 1,4-dioxane (3 mL). The mixture was stirred at 90° C. for 1 h, poured into water, acidified with HCl (2N) and extracted with EtOAc. The organic extracts were dried over MgSO4. Evaporation and crystallization from EtOAc/hexanes, gave a white solid (0.06 g, 46% yield, m.p. 250-252° C.); MS m/e 272 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06794403B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_09 |
|---|
| ORD ID | ord-b4d4bb56d1da409d8a90bcfd9295bfa8 |
|---|
| 출처 메모 | uspto-grants-2004_09 |
|---|
