참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dopac | HCID 547 | — |
| 반응물 | Diethyl Sulfate | HCID 6163 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium bisulfate | HCID 516920 | — |
| 반응물 | Barium hydroxide, octahydrate | HCID 17749109 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3,4-Diethoxyphenylacetic acid | HCID 579813 | — |
반응 단계
0.8 g of 3,4-dihydroxy-phenylacetic acid and 6.9 g of barium hydroxide octahydrate are dissolved in 50 ml of water and at ambient temperature 2.9 ml of diethylsulphate are added dropwise. The solution is stirred for 2 hours at ambient temperature and for 2 hours at 40° C. After this time the solution is acidified with saturated potassium hydrogen sulphate solution, mixed with ethyl acetate and the suspension is filtered through Celite. The phases are separated and the ethyl acetate phase is dried over sodium sulphate and concentrated by evaporation. The residue obtained is purified through a silica gel column with toluene/ethyl acetate/ethanol (4:2:1) as eluant.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06794395B1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_09 |
|---|
| ORD ID | ord-4b67fc642c024da69356a00d8d3e23ff |
|---|
| 출처 메모 | uspto-grants-2004_09 |
|---|
