Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(Formyloxy)acetonitrile → (s)-n-Formyl-beta-cyclopropylalanine tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (Formyloxy)acetonitrile | HCID 4205685 | — |
| 반응물 | (S)-tert-Butyl 2-amino-3-cyclopropylpropanoate | HCID 12018345 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (s)-n-Formyl-beta-cyclopropylalanine tert-butyl ester | HCID 12018346 | — |
반응 단계
A mixture of 10 g (54 mmol) of (S)-β-cyclopropylalanine tert-butyl ester and 4.7 g (55.2 mmol) of cyanomethyl formate in 100 mL of dichloromethane was stirred at room temperature overnight. The residue obtained after removal of the solvent in vacuo was distilled in vacuo. Yield: 8.8 g (76%). Boiling point 120° C./40 Pa (0.3 torr).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06794517B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-fa7a2359d00246fbaccb855bb320c870 |
| 출처 메모 | uspto-grants-2004_09 |