Methanol → 3-Hydroxy-4-methoxybenzenepropanoic acid
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[CH:5]=[CH:6][C:7]([OH:9])=[O:8].CO>O.[C].[Pd]>[OH:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][C:7]([OH:9])=[O:8])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
3-Hydroxy-4-methoxycinnamic acid (15.0 g, 77.2 mmo) and 10% palladium carbon in the water content of 50% (2.26 g) were added to a mixed solvent (330 ml) of methanol and water (mixing ratio of 10:1 v/v), and the mixture was stirred under hydrogen atmosphere of normal pressure (0.1 MPa) at 50° C. for 5 hours for reaction. The reaction solution was filtrated to remove the catalyst, and the filtrate was concentrated under reduced pressure to solidification to obtain 3-(3-hydroxy-4-methoxyphenyl) propionic acid (15.1 g, 76.7 mmol, yield: 99%).
후처리
- filtrationThe reaction solution was filtrated
- customto remove the catalyst
- concentrationthe filtrate was concentrated under reduced pressure to solidification
출처 및 근거
- ORD 기록
- ord-48c93856764741ffacd57281a88c3f51
- 출처 데이터셋
- uspto-grants-2004_09
- 특허 번호
- US06794531B2
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