Acetic Acid → N-BOC-2-cyclohexylethylamine
반응식
[C:1]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(O)(=O)C>CO.[Rh]>[C:1]([NH:8][CH2:9][CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]참가 물질
5
실험 절차
N-BOC-2-phenylethylamine (3.1 g) and 5% rhodium on alumina (1.1 g) are combined in methanol (40 ml) containing acetic acid (1.0 ml). The mixture is shaken under hydrogen at 50 psi for about 20 hours. The mixture is filtered, evaporated in vacuo, and the residue taken up into ethyl acetate. The organic solution is washed with water, 5% sodium bicarbonate solution, water, brine, dried over sodium sulfate, filtered, and evaporated in vacuo to to give N-BOC-2-cyclohexylethylamine.
후처리
- filtrationThe mixture is filtered
- customevaporated in vacuo
- washThe organic solution is washed with water, 5% sodium bicarbonate solution, water, brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-335b938de8c24b6eb7e77d0091b604bd
- 출처 데이터셋
- uspto-grants-2004_09
- 특허 번호
- US06797700B2
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