Ethyl isobutyrylacetate → HCID 69052716, 화합물

HRID 1008150노트

반응식

HRID 1008150 반응식
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[C:12]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(=O)[CH:13]([CH3:15])[CH3:14].C([O-])(=O)C.[Na+]>O>[CH2:21]([O:20][C:18]([C:17]1[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[CH:3][NH:2][C:12]=1[CH:13]([CH3:15])[CH3:14])=[O:19])[CH3:22]

참가 물질

5

반응물 3

HCID 81583Ethyl isobutyrylacetateHCID 517045Sodium AcetateHCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)

생성물 1

HCID 69052716HCID 69052716, 화합물수율 93%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-aminoacetophenone hydrochloride (1 equiv.), ethyl isobutyrylacetate (1.2 equiv.) and sodium acetate (2.4 equiv.) in H2O was stirred at 100° C. for 18 hours and then cooled to room temperature. The aqueous layer was decanted off and the oil was dissolved in ethyl acetate. It was then washed with water and brine and then dried to give (93%) of 2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester as a red brown oil.

후처리

  1. temperaturecooled to room temperature
  2. customThe aqueous layer was decanted off
  3. dissolutionthe oil was dissolved in ethyl acetate
  4. washIt was then washed with water and brine
  5. customdried

출처 및 근거

ORD 기록
ord-3b5dfa553842483c8451239085d5cab0
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06797725B2

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