4-(3-Fluoro-4-nitrophenoxy)-6-methoxy-7-(phenylmethoxy)quinoline → HCID 135674219, 화합물

HRID 1008331노트

반응식

HRID 1008331 반응식
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[C:22]([F:29])[CH:21]=3)=[CH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:30][CH3:31])C1C=CC=CC=1.[H][H]>CN(C)C=O.C(N(CC)CC)C.[OH-].[Pd+2].[OH-]>[NH2:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][C:13]2[C:12]3[C:17](=[CH:18][C:9]([OH:8])=[C:10]([O:30][CH3:31])[CH:11]=3)[N:16]=[CH:15][CH:14]=2)=[CH:21][C:22]=1[F:29]

참가 물질

6

반응물 2

HCID 226671344-(3-Fluoro-4-nitrophenoxy)-6-methoxy-7-(phenylmethoxy)quinolineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 135674219HCID 135674219, 화합물수율 56%

시약·촉매·용매 3

HCID 9942167Palladium hydroxide촉매HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

7-(Benzyloxy)-4-(3-fluoro-4-nitrophenoxy)-6-methoxyquinoline (190 mg) was dissolved in N,N-dimethylformamide (5 ml) and triethylamine (1 ml). Palladium hydroxide (40 mg) was added to the solution, and the mixture was stirred in a hydrogen atmosphere at room temperature overnight. The solvent was removed by distillation under the reduced pressure. The residue was purified by thin-layer chromatography on silica gel by development with chloroform/methanol (20/1) to give 75 mg (yield 56%) of the title compound.

후처리

  1. customThe solvent was removed by distillation under the reduced pressure
  2. customThe residue was purified by thin-layer chromatography on silica gel by development with chloroform/methanol (20/1)

출처 및 근거

ORD 기록
ord-ad91409be7dc43c4ad65b3bf73700457
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06797823B1

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