Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloride → HCID 86758419, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | (4S)-5-(tert-Butoxy)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid | HCID 7017912 | — |
| 반응물 | 1,1-Dimethylethyl 1-[(1-amino-6-isoquinolinyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl-carbamate | HCID 22665607 | — |
| 반응물 | N-[1-[(1-Amino-6-isoquinolinyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl]-2-[[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino]acetamide hydrochloride | HCID 22665631 | — |
| 반응물 | HCID 86758418 | HCID 86758418 | — |
| 반응물 | HCID 131723437 | HCID 131723437 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 86758419 | HCID 86758419 | — |
반응 단계
The procedure described for 5c was used. Deprotection of 5a and coupling with Mtr-Glu(OEt)-OH (prepared from Fmoc-Glu-OtBu, ethanol and Mtr-chloride according to the procedure described for 51a) yielded after purification the title compound (76%) as a mixture of diastereomers (1:1). 1H-NMR 400 Hz (CD3OD) δ: 1.15-2.32 (11H, m), 2.13 (3H, s), 2.40 and 2.42 (3H, 2× s), 2.44 and 2.47 (3H, 2× s), 2.75-4.08 (11H, m), 4.99-5.19 (1H, m), 6.71 and 6.72 (1H, 2× s), 7.16-7.20 (1H, m), 7.51-7.76 (3H, m), 8.30-8.36 (1H, m).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06797710B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-26e1b56df2ef4439989b94017b25b6d3 |
| 출처 메모 | uspto-grants-2004_09 |