Quinuclidine → 1-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

HRID 1008756노트

반응식

HRID 1008756 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:9][CH2:10][CH2:11][CH2:12][N:13]=[C:14]=[S:15]>C(#N)C>[Br-:9].[N:13]([CH2:12][CH2:11][CH2:10][N+:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2)=[C:14]=[S:15]

참가 물질

4

반응물 2

HCID 7527QuinuclidineHCID 1377143-Bromopropyl isothiocyanate

생성물 1

HCID 231542151-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
50 °C

실험 절차

Quinuclidine (33 mg) was added to a solution of 55 mg of 3-bromopropyl isothiocyanate in 1 mL of acetonitrile, and heated at 50° C. for 19 hours. The reaction solution was concentrated and then a residue was washed three times with 1 mL of ether, to yield the title compound.

후처리

  1. concentrationThe reaction solution was concentrated
  2. washa residue was washed three times with 1 mL of ether

출처 및 근거

ORD 기록
ord-66e2c863a0c248eaadb9ccbc1142e6fc
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973030B2

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