Bromine → 5-Bromo-4-ethylthiazol-2-amine

HRID 1009024노트

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HRID 1009024 반응식
[CH2:1]([C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1)[CH3:2].[Br:9]Br>S(=O)(=O)(O)O>[Br:9][C:7]1[S:6][C:5]([NH2:8])=[N:4][C:3]=1[CH2:1][CH3:2]

참가 물질

4

반응물 2

HCID 24408BromineHCID 123782054-Ethyl-1,3-thiazol-2-amine

생성물 1

HCID 665201935-Bromo-4-ethylthiazol-2-amine

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
0 °C

실험 절차

The above prepared 4-ethyl-thiazol-2-ylamine (1.125 g, 8.77 mmol) was dissolved in 4.5 mL of 20% aq. sulfuric acid, cooled to 0° C., and treated with Br2 (0.494 mL, 1.1 eq.). After 10 Min., the reaction mixture was carefully poured onto crashed ice/Na2CO3, twofold extracted with ethyl acetate, washed with water, dried over sodium sulfate, and evaporated to dryness. Thereby, 1.306 g of the title compound was obtained as light brown viscous oil, sufficiently pure to be used for the next step.

후처리

  1. addition, the reaction mixture was carefully poured
  2. extractiontwofold extracted with ethyl acetate
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-fa9f99eb0d5942bb87242111f3aa8147
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973051B2

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