Tert-butyl (5-ethynyl-4-methylthiazol-2-yl)carbamate → HCID 86630952, 화합물

HRID 1009034노트

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HRID 1009034 반응식
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[S:9][C:10]([C:14]#[CH:15])=[C:11]([CH3:13])[N:12]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[S:9][C:10]([CH2:14][CH3:15])=[C:11]([CH3:13])[N:12]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 86630951Tert-butyl (5-ethynyl-4-methylthiazol-2-yl)carbamate

생성물 1

HCID 86630952HCID 86630952, 화합물수율 92.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

The above prepared (5-ethynyl-4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (0.420 g, 1.76 mmol) was dissolved in 12 mL of ethyl acetate and hydrogenated over 0.200 g of Pd on charcoal (10%) at atmospheric pressure and ambient temperature over night. Filtration over a pad of Celite and evaporation off all solvents yielded 0.396 g of the title product as light brown viscous oil, sufficiently pure for the next step.

후처리

  1. filtrationFiltration
  2. customover a pad of Celite and evaporation off all solvents

출처 및 근거

ORD 기록
ord-81f38227d37f4ede8ea8309cfe12dee0
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973051B2

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