Sodium methanethiolate → 4-Methyl-5-(methylsulfanyl)-1,3-thiazol-2-amine
반응식
Br[C:2]1[S:6][C:5]([NH2:7])=[N:4][C:3]=1[CH3:8].[CH3:9][S-:10].[Na+]>CO>[CH3:8][C:3]1[N:4]=[C:5]([NH2:7])[S:6][C:2]=1[S:10][CH3:9]참가 물질
4
실험 절차
5-Bromo-4-methyl-thiazol-2-ylamine (1.35 g, 7 mmol,) was dissolved in methanol abs. (13.5mL) and sodium methanethiolate (0.6 g, 7.7 mmol) 1.1 equiv.) was added portionwise at rt. After stirring overnight, the dark colored mixture was concentrated under reduced pressure and purified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent. The desired fractions were evaporated to give the title compound as a light yellow solid: 180 mg, MS (ISP): m/e 161.1 (M+H)+
후처리
- concentrationthe dark colored mixture was concentrated under reduced pressure
- custompurified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent
- customThe desired fractions were evaporated
출처 및 근거
- ORD 기록
- ord-99a3bb1bee3d470295e3d3edce32c9b4
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973051B2
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