3-Hydroxybenzaldehyde → 3-(1-Methyl-cyclohexylmethoxy)-benzaldehyde

HRID 1009184노트

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HRID 1009184 반응식
[CH3:1][C:2]1([CH2:8][O:9]S(C(F)(F)F)(=O)=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.O[C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=[O:22].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[CH3:1][C:2]1([CH2:8][O:9][C:18]2[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=2)[CH:21]=[O:22])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 1013-HydroxybenzaldehydeHCID 962WaterHCID 11430Potassium CarbonateHCID 24827766(1-Methylcyclohexyl)methyl trifluoromethanesulfonate

생성물 1

HCID 248277673-(1-Methyl-cyclohexylmethoxy)-benzaldehyde수율 44%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
80 °C

실험 절차

A mixture of compound iii (0.5 mmol), 3-hydroxy-benzaldehyde (iv, 0.6 mmol) and K2CO3 (0.7 mmol) were dissolved in DMF (3 mL). The solution was heated to 80° C. for 4 hr. The solution was poured into water, extracted with ethyl acetate (10 mL) three times, and concentrated. The residue was purified by chromatography and resulted in 0.22 mmol of 3-(1-methyl-cyclohexylmethoxy)-benzaldehyde (v) with a 44% yield.

후처리

  1. extractionextracted with ethyl acetate (10 mL) three times
  2. concentrationconcentrated
  3. customThe residue was purified by chromatography

출처 및 근거

ORD 기록
ord-edbca64020464f188b204f229474d3e7
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973062B2

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