Thionyl Chloride → 4-(Trifluoromethoxy)phenoxyacetyl chloride

HRID 1009193노트

반응식

HRID 1009193 반응식
[F:1][C:2]([F:16])([F:15])[O:3][C:4]1[CH:14]=[CH:13][C:7]([O:8][CH2:9][C:10](O)=[O:11])=[CH:6][CH:5]=1.S(Cl)([Cl:19])=O>CN(C=O)C>[F:1][C:2]([F:16])([F:15])[O:3][C:4]1[CH:14]=[CH:13][C:7]([O:8][CH2:9][C:10]([Cl:19])=[O:11])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 6977052-(4-(Trifluoromethoxy)phenoxy)acetic acid

생성물 1

HCID 27773084-(Trifluoromethoxy)phenoxyacetyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

(4-Trifluoromethoxyphenoxy)-acetic acid (20.7 g, 88 mmol) was dissolved in thionyl chloride (100 mL). DMF (3 drops) was added to the solution. The solution was stirred for 14 hours. The thionyl chloride was removed in vacuo. The resulting oil was dissolved in dichloromethane, filtered through sodium sulfate and concentrate in vacuo to afford the title compound as a paste-like solid (21.8 g, 97% from the phenol): MS (EI-GCMS) for C9H6ClF3O3: 254 (M+).

후처리

  1. customThe thionyl chloride was removed in vacuo
  2. dissolutionThe resulting oil was dissolved in dichloromethane
  3. filtrationfiltered through sodium sulfate
  4. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-008a93ab7eb44053911af6dbbb4c8df6
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973061B2

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