4-Fluorobenzaldehyde → (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol
반응식
[NH2:1][C@H:2]([CH2:7][OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1>C1C=CC=CC=1>[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[N:1][C@@H:2]([CH2:3][CH:4]([CH3:6])[CH3:5])[CH2:7][OH:8])=[CH:12][CH:11]=1참가 물질
4
실험 절차
A mixture of (L)-leucinol (1.13 g, 9.67 mmol) and 4-fluorobenzaldehyde (1.20 g, 9.67 mmol) was dissolved in benzene (30 mL) and heated at reflux for 1 hour, using a Dean-Stark apparatus to remove water. (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol was isolated by concentration in vacuo, and was used immediately without further purification.
후처리
- temperatureheated
- temperatureat reflux for 1 hour
- customto remove water
출처 및 근거
- ORD 기록
- ord-c608941437834900a7d76eeb2e50d0c7
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973037B2
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