Hydrazine → 2-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide

HRID 1009407노트

반응식

HRID 1009407 반응식
[NH2:1][NH2:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([O:16][CH3:17])[CH2:14][CH2:13][O:12][C:11]2=[O:15])=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([O:16][CH3:17])([CH2:14][CH2:13][OH:12])[C:11]([NH:1][NH2:2])=[O:15])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 670671553-(4-Fluorophenyl)-3-methoxydihydrofuran-2-one

생성물 1

HCID 670673452-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide수율 96.2%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of hydrazine (29 mg) in ethanol (0.5 mL) was added to a solution of 3-(4-fluorophenyl)-3-methoxydihydrofuran-2-one (37 mg) in ethanol (1.2 mL), and the reaction solution was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure to obtain 41 mg of the title compound. The property values of the compound are as follows.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3236e39468244beab41279eed019e212
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973033B2

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