Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Tert-Butylaniline | HCID 69861 | — |
| 반응물 | 4-Chloro-3-methoxy-2-methylpyridine | HCID 10583046 | — |
| 용매 | Phenol | HCID 996 | — |
| 생성물 | 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine | HCID 19693953 | — |
반응 단계
7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723450 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-ed5d30e63cae482aa9ed8a44a63361f9 |
| 출처 메모 | uspto-grants-1998_03 |