Ethyl acetate hexane → phenyl N-(3-fluoropropyl)carbamate

반응식

Cl.[F:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:13]([O:16]CC)(=[O:15])C>>[F:2][CH2:3][CH2:4][CH2:5][NH:6][C:13](=[O:15])[O:16][C:9]1[CH:8]=[CH:7][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 21226206Ethyl acetate hexane

HCID 219074553-Fluoropropan-1-amine hydrochloride

생성물 1

HCID 22936322phenyl N-(3-fluoropropyl)carbamate수율 29.42%

실험 절차

3-Fluoropropylamine hydrochloride (0.92 g (wet), 8.10 mmol) was used for reaction in the same manner as Production Example 310-1, and purification was performed by silica gel column chromatography (hexane/ethyl acetate system) to obtain the title compound (0.470 g, 2.3832 mmol, 29.42%) as pink crystals.

출처 및 근거

ORD 기록: ord-a278c19c591c4f2ba27156438a0a645d
출처 데이터셋: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07973160B2

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