Ethanol → 4-(4-Aminophenoxy)-N-(cyclopropylmethyl)picolinamide

HRID 1010321노트

반응식

HRID 1010321 반응식
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[CH:13]=[C:12]([O:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[O:7])[CH2:3][CH2:2]1.[Cl-].[NH4+].C(O)C.CN(C)C=O>[Fe].O>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][C:12]2[CH:11]=[CH:10][N:9]=[C:8]([C:6]([NH:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)=[O:7])[CH:13]=2)=[CH:16][CH:17]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 6228DimethylformamideHCID 25517Ammonium ChlorideHCID 229368972-[(Cyclopropylmethyl)aminocarbonyl]-4-(4-nitrophenoxy)pyridine

생성물 1

HCID 589311534-(4-Aminophenoxy)-N-(cyclopropylmethyl)picolinamide

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

After adding 0.35 g of 2-[(cyclopropylmethyl)aminocarbonyl]-4-(4-nitrophenoxy)pyridine to a mixture of 0.7 g of iron powder, 1.4 g of ammonium chloride, 10 ml of ethanol, 10 ml of dimethylformamide and 5 ml of water, the mixture was vigorously stirred at 100° C. for 20 minutes. The reaction solution was filtered with celite and the solvent was distilled off under reduced pressure to obtain 0.37 g of the target substance as a light brown oil.

후처리

  1. filtrationThe reaction solution was filtered with celite
  2. distillationthe solvent was distilled off under reduced pressure
  3. customto obtain 0.37 g of the target substance as a light brown oil

출처 및 근거

ORD 기록
ord-e5fe274638a94df39804b2ad957cdf89
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973160B2

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