5-Benzyl-5-azaspiro[2.4]heptan-7-one → 5-Benzyl-7-methylene-5-azaspiro[2.4]heptane

HRID 1010803노트

반응식

HRID 1010803 반응식
[CH2:1]([N:8]1[CH2:14][C:13](=O)[C:10]2([CH2:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[Zn][CH2:18][Zn]C[Zn]Br.C1OCCC1>O1CCCC1>[CH2:1]([N:8]1[CH2:14][C:13](=[CH2:18])[C:10]2([CH2:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 103527905-Benzyl-5-azaspiro[2.4]heptan-7-oneHCID 178420636HCID 178420636, 화합물

생성물 1

HCID 167351155-Benzyl-7-methylene-5-azaspiro[2.4]heptane

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5-benzyl-5-azaspiro[2.4]heptan-7-one (300 mg) was dissolved into anhydrous tetrahydrofuran (10 ml) and Nysted reagent (1.5 eq, 20% solution) was added to the reaction. The reaction was stirred at RT for two days and quenched with NH4Cl solution and extracted with EtOAc followed by washing with water, then brine and dried over Na2SO4 and purified with silica gel column to give the titled compound. Mass: (M+1), 200

후처리

  1. additionwas added to the reaction
  2. customquenched with NH4Cl solution
  3. extractionextracted with EtOAc
  4. washby washing with water
  5. dry with materialbrine and dried over Na2SO4
  6. custompurified with silica gel column

출처 및 근거

ORD 기록
ord-670c83ba180e48f8ab407d800d63c3a5
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977346B2

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