홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-Aminopyridine → HCID 21104347, 화합물

HRID 1010829
노트
인쇄 미리보기

반응식

HRID 1010829 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[N:5]=[C:4]2[N:15]([CH3:19])[N:16]=[C:17]([CH3:18])[C:3]=12.[NH2:20][C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1>C(O)(C)C.Cl.O1CCOCC1>[F:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:6]1[N:5]=[C:4]2[N:15]([CH3:19])[N:16]=[C:17]([CH3:18])[C:3]2=[C:2]([NH:20][C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[N:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 17274-AminopyridineHCID 21104341HCID 21104341, 화합물

생성물 1

HCID 21104347HCID 21104347, 화합물수율 81%

시약·촉매·용매 2

HCID 204431481,4-Dioxane hydrochloride촉매HCID 3776Isopropanol용매

반응 조건

온도
80 °C

실험 절차

4-Chloro-6-(2-fluoro-phenyl)-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine (84 mg, 0.304 mmole) and 4-aminopyridine (57 mg, 0.608 mmole) were combined in 4 ml isopropanol, 3 drops 4M HCl/dioxane were added and the reaction mixture heated to 80° C. for 5 hours. The reaction mixture was cooled and the product was filtered to obtain 83 mg after vacuum drying (yield: 81%).

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe product was filtered
  3. customto obtain 83 mg after vacuum
  4. customdrying (yield: 81%)

출처 및 근거

ORD 기록
ord-386caaa3415e4d0891bb2418b860a44b
출처 데이터셋
uspto-grants-2011_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07977342B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트