HCID 67313552, 화합물 → HCID 131729000, 화합물

HRID 1010882노트

반응식

HRID 1010882 반응식
C(O[C:9](=O)[N:10]([CH2:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([C@@H:21]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH3:22])=[CH:17][CH:16]=1)=[O:14])C)C1C=CC=CC=1>O1CCCC1.CO.[C].[Pd]>[C:27]([O:26][C:24](=[O:25])[NH:23][C@H:21]([C:18]1[CH:17]=[CH:16][C:15]([C:13](=[O:14])[CH2:12][NH:10][CH3:9])=[CH:20][CH:19]=1)[CH3:22])([CH3:29])([CH3:28])[CH3:30]

참가 물질

5

반응물 1

HCID 67313552HCID 67313552, 화합물

생성물 1

HCID 131729000HCID 131729000, 화합물

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매2회HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

159 mg of the compound [2-2] was dissolved in a mixed solvent of 4 mL of tetrahydrofuran and 2 mL of methanol, then 48 mg of 10% palladium carbon catalyst was added thereto, and the mixture was further stirred for 2 hours under hydrogen atmosphere. Thereto, 95 mg of 10% palladium carbon catalyst was further added and stirred for 3.5 hours under hydrogen atmosphere. The insolubles were filtered through celite and the filtrate was concentrated under reduced pressure, to obtain tert-butyl{(1S)-1-[4-(N-methylglycyl)phenyl]ethyl}carbamate [2-3] (hereinafter, referred to as the compound [2-3]) as crude and purified products. The compound [2-3] was used in the subsequent reaction without further purification.

후처리

  1. stirringstirred for 3.5 hours under hydrogen atmosphere
  2. filtrationThe insolubles were filtered through celite
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ace09b96cbd6480cb26001bb573d6e38
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977336B2

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