Triethylamine → 2-(Tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate

HRID 1010944

반응식

HRID 1010944 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[CH3:17][S:18]([O:9][CH2:8][CH2:7][CH:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)(=[O:20])=[O:19]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 177509442-(Oxan-4-yl)ethan-1-ol

생성물 1

HCID 222730832-(Tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 2-(tetrahydro-2H-pyran-4-yl)ethanol (3,3 g) in dry dichloromethane (100 ml) at 0° C. and under nitrogen was added triethylamine (4.6 ml), followed by methanesulphonyl chloride (2.6 ml) dropwise over 5 minutes. The reaction was stirred until the ice in the bath melted and left overnight at room temperature. The reaction was washed with saturated aqueous sodium bicarbonate (40 ml). The organic layer was dried by passing through a hydrophobic frit and concentrated in vacuo to yield the title compound as a yellow oil (5.4 g).

후처리

  1. washThe reaction was washed with saturated aqueous sodium bicarbonate (40 ml)
  2. customThe organic layer was dried
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9d4b9e3c68084152b087ac5b379cc57c
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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