Trifluoroacetic acid → 2-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9h-purin-6-amine trifluoroacetic acid salt

HRID 1010949노트

반응식

HRID 1010949 반응식
[CH3:1][C:2]([CH3:26])([CH2:23][CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[N:11]2C2CCCCO2)=[C:7]([NH2:22])[N:6]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>CO>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[CH3:1][C:2]([CH3:26])([CH2:23][CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[NH:11]2)=[C:7]([NH2:22])[N:6]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 576996322-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

생성물 1

HCID 1784440732-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9h-purin-6-amine trifluoroacetic acid salt

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-[(2,2-dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (323 mg) in dry MeOH (3.23 mL) was added TFA (0.323 mL) and the reaction was stirred at room temperature for 48 h. The reaction was concentrated in vacuo to give a yellow residue. The residue was triturated with Et2O and was filtered to give the title compound as an off-white solid (252 mg).

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue
  3. customThe residue was triturated with Et2O
  4. filtrationwas filtered

출처 및 근거

ORD 기록
ord-0cef73a619304326896e486b2f08b258
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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