Sodium Methoxide → HCID 57699783, 화합물

HRID 1010958노트

반응식

HRID 1010958 반응식
Br[C:2]1[N:3]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[C:4]2[C:9]([N:10]=1)=[C:8]([NH2:11])[N:7]=[C:6]([O:12][CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[N:5]=2.[CH3:24][O-:25].[Na+]>CCOC(C)=O>[CH3:16][CH:15]([CH3:17])[CH2:14][CH2:13][O:12][C:6]1[N:5]=[C:4]2[C:9]([N:10]=[C:2]([O:25][CH3:24])[N:3]2[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)=[C:8]([NH2:11])[N:7]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 576996758-Bromo-2-[(3-methylbutyl)oxy]-9-(tetrahydro-2H-Pyran-2-yl)-9H-Purin-6-amine

생성물 1

HCID 57699783HCID 57699783, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 8-bromo-2-[(3-methylbutyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (314 mg) was added sodium methoxide solution (0.460 mL, 30% wt. MeOH) and the mixture was stirred at reflux for 4 h. The reaction was allowed to cool and was concentrated in vacuo to give an orange residue. The residue was taken up in EtOAc (20 mL) and was extracted with saturated ammonium chloride solution (20 mL), followed by water (20 mL). The organics were separated, dried over MgSO4, filtered and concentrated in vacuo to give the title compound as a light orange solid (210 mg).

후처리

  1. temperatureat reflux for 4 h
  2. temperatureto cool
  3. concentrationwas concentrated in vacuo
  4. customto give an orange residue
  5. extractionwas extracted with saturated ammonium chloride solution (20 mL)
  6. customThe organics were separated
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-010b1a3da70b47dcbc620ff88b2302d7
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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