Trifluoroacetic acid → HCID 178493996, 화합물

HRID 1010959노트

반응식

HRID 1010959 반응식
[CH3:1][CH:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:21][CH3:22])[N:12]2C2CCCCO2)=[C:8]([NH2:23])[N:7]=1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:21][CH3:22])[NH:12]2)=[C:8]([NH2:23])[N:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57699783HCID 57699783, 화합물

생성물 1

HCID 178493996HCID 178493996, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-[(3-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (210 mg) in dry MeOH (2.1 mL) was added TFA (0.21 ml) and the mixture was stirred at room temperature for 24 h. The reaction was concentrated in vacuo to give a yellow residue which was triturated with Et2O (15 mL) and filtered under reduced pressure to give the title compound as an off-white solid (143 mg).

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O (15 mL)
  4. filtrationfiltered under reduced pressure

출처 및 근거

ORD 기록
ord-bb1f24f3bd604e7887cfaed5fefa6890
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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